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The usual starting dose is 20 to 40 milligrams once a day in the evening. If your cholesterol level or heart attack risk is especially high, the doctor may start with a dose of 40 milligrams. The dosage can be adjusted every 4 weeks. Some people with severe, hereditary high cholesterol may be prescribed as much as 80 milligrams a day, taken in doses of 20, 20, and 40 milligrams, along with other treatments.

Those who have severe kidney disease should use Zocor with caution. The recommended starting dose is 5 milligrams per day.

When combined with cyclosporine, niacin, gemfibrozil, or fenofibrate, the dosage of Zocor should not exceed 10 milligrams a day. When combined with amiodarone, the dosage of Zocor should not exceed 20 milligrams a day.

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